| Season | Team | Competition | MP | G | A | Rating | ||
|---|---|---|---|---|---|---|---|---|
| 2024/2025 | Taranto | Serie C | 19 | 0 | 0 | 10 | 0 | – |
| 2023/2024 | Fermana | Serie C | 4 | 0 | 0 | 0 | 0 | – |
| 2023/2024 | Taranto | Serie C | 9 | 0 | 0 | 3 | 0 | – |
| 2022/2023 | Monopoli | Serie C | 30 | 2 | 0 | 8 | 0 | – |
| 2021/2022 | Paganese | Serie C | 18 | 0 | 0 | 5 | 0 | – |
| 2021/2022 | Monopoli | Serie C | 0 | 0 | 0 | 0 | 0 | – |
| 2020/2021 | Modena | Serie C | 5 | 0 | 0 | 0 | 0 | – |
| 2020/2021 | Virtus Entella | Serie B | 1 | 0 | 0 | 0 | 0 | 6.3 |
| 2019/2020 | Cesena | Serie C | 4 | 0 | 0 | 1 | 0 | – |
| 2019/2020 | Virtus Entella | Serie B | 1 | 0 | 0 | 0 | 0 | 6.2 |
| 2018/2019 | Virtus Entella | Serie C | 11 | 0 | 0 | 2 | 0 | – |
| 2018/2019 | Ascoli | Serie B | 3 | 0 | 0 | 0 | 0 | – |
| 2017/2018 | Ascoli | Serie B | 23 | 1 | 0 | 4 | 0 | – |
| 2016/2017 | Paganese | Serie C | 16 | 1 | 0 | 4 | 0 | – |
| 2016/2017 | Catania | Serie C | 2 | 0 | 0 | 0 | 0 | – |
| 2015/2016 | AC Milan | Serie A | 0 | 0 | 0 | 0 | 0 | – |
| 2014/2015 | AC Milan | Serie A | 0 | 0 | 0 | 0 | 0 | – |
| Total | 146 | 4 | 0 | 37 | 0 | – | ||
| Date | From | To | Type | |
|---|---|---|---|---|
| 07 Jan 2024 | Fermana | Taranto | N/A | |
| - | Taranto | Fermana | Loan | |
| - | Monopoli | Taranto | N/A | |
| 07 Jan 2022 | Paganese | Monopoli | N/A | |
| - | Virtus Entella | Paganese | Loan | |
| - | Virtus Entella | Monopoli | Loan | |
| - | Virtus Entella | Modena | Loan | |
| 09 Jan 2020 | Cesena | Virtus Entella | N/A | |
| - | Virtus Entella | Cesena | Loan | |
| 07 Feb 2019 | Ascoli | Virtus Entella | N/A | |
| 07 Jan 2019 | Virtus Entella | Ascoli | N/A | |
| 01 Aug 2019 | Ascoli | Virtus Entella | Loan | |
| 08 Feb 2017 | Milan | Ascoli | N/A | |
| - | Milan | Paganese | Loan | |
| - | Milan | Catania | Loan |
I. De Santis career history shows progression across clubs and competitions, including club timeline, national team appearances and overall career totals.