Matarazzo's and Simeone's teams have gained significant advantages in the first leg of the Copa del Rey semi-finals and are the clear favourites to reach the final in Seville.
The Argentine striker for Atlético Madrid has not scored in two months. His last goal was on 9 December against PSV in the sixth match of the Champions League group stage.
Barcelona, Real Sociedad, Athletic and Atlético Madrid will contest the Copa del Rey semi-finals after coming through their quarter-final ties.